ChatGPT in Teaching and Learning: A Systematic Review. Educ. Sci. 2024, 14(6), 643; https://doi.org/10.3390/educsci14060643. Submission received: 10 April 2024 / Revised: 10 June 2024 / Accepted: 12 June 2024 / Published: 14 June 2024 (This article belongs to the Special Issue Artificial Intelligence and Blended Learning: Challenges, Opportunities, and Future Directions) – “The increasing use of artificial intelligence (AI) in education has raised questions about the implications of ChatGPT for teaching and learning. A systematic literature review was conducted to answer these questions, analyzing 112 scholarly articles to identify the potential benefits and challenges related to ChatGPT use in educational settings. The selection process was thorough to ensure a comprehensive analysis of the current academic discourse on AI tools in education. Our research sheds light on the significant impact of ChatGPT on improving student engagement and accessibility and the critical issues that need to be considered, including concerns about the quality and bias of generated responses, the risk of plagiarism, and the authenticity of educational content. The study aims to summarize the utilizations of ChatGPT in teaching and learning by addressing the identified benefits and challenges through targeted strategies. The authors outlined some recommendations that will ensure that the integration of ChatGPT into educational frameworks enhances learning outcomes while safeguarding academic standards.”