“In September 2007, ClinicalTrials.gov will launch a new user interface, which represents the first significant change to the interface since February 2000. The new user interface will run in parallel with the previous version and after appropriate testing, the new user interface will permanently replace the previous version (approximately two to four weeks after launch). This article describes the new features, including highlighted search terms, more display options, and additional capabilities for viewing studies and search results by topic. Improvements were also made to “Advanced Search” and the display by location on the world map.”