Emily C. Somers, Martha A. Ganser, Jeffrey S. Warren, Niladri Basu, Lu Wang, Suzanna M. Zick, Sung Kyun Park. Mercury Exposure and Antinuclear Antibodies among Females of Reproductive Age in the United States: NHANES. Environmental Health Perspectives, 2015; DOI: 10.1289/ehp.1408751

Science Daily: “One of the greatest risk factors for autoimmunity among women of childbearing age may be associated with exposure to mercury such as through seafood, a new University of Michigan study says.The findings, which appear in Environmental Health Perspectives, found that mercury — even at low levels generally considered safe — was associated with autoimmunity. Autoimmune disorders, which cause the body’s immune system to attack healthy cells by mistake, affects nearly 50 million Americans and predominately women.  “We don’t have a very good sense of why people develop autoimmune disorders,” says lead author Emily Somers, Ph.D., Sc.M, an associate professor in the departments of Internal Medicine in the division of Rheumatology, Environmental Health Sciences, and Obstetrics & Gynecology at the U-M Medical and Public Health Schools. “A large number of cases are not explained by genetics, so we believe studying environmental factors will help us understand why autoimmunity happens and how we may be able to intervene to improve health outcomes. In our study, exposure to mercury stood out as the main risk factor for autoimmunity.” Autoimmune disease — which can include such conditions as inflammatory bowel disease, lupus, Sjögren’s syndrome, rheumatoid arthritis and multiple sclerosis — is among the 10 leading causes of death among women. Researchers analyzed data among women ages 16-49 from the National Health and Nutrition Examination Survey from 1999-2004. Greater exposure to mercury was associated with a higher rate of autoantibodies, a precursor to autoimmune disease. Most autoimmune diseases are characterized by autoantibodies, proteins made by a person’s immune system when it fails to distinguish between its own tissues and potentially harmful cells.”