“On December 18, 2017, the National Library of Medicine (NLM) released a new set of updates to ClinicalTrials.gov as part of its ongoing effort to enhance the usability of the database (see ClinicalTrials.gov: First in a Series of Changes to Improve Usability for Stakeholders). Most of the features provided in the current release were previously available for public testing on the beta site starting in November (see New ClinicalTrials.gov Beta Version Available for Public Testing). This article highlights newly added key features, which were informed by research with end-users representing various stakeholder groups and the NLM partnership with 18F, a federal government digital services consultancy. Information about future changes to ClinicalTrials.gov will be provided on a new What’s New page. ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world operated by NLM. The database contains information on over 261,000 clinical studies and expanded access (or “compassionate use”) to investigational new drugs. Summary results entries for over 29,000 of these studies are also posted in a tabular format on ClinicalTrials.gov. Information listed on ClinicalTrials.gov is provided and updated by the study sponsor or investigator, and listing does not mean it has been evaluated by the U.S. Federal Government…”