Nature Biotechnology (2013). doi:10.1038/nbt.2487. Published online January 20 2013. “Epigenetic mechanisms integrate genetic and environmental causes of disease, but comprehensive genome-wide analyses of epigenetic modifications have not yet demonstrated robust association with common diseases. Using Illumina HumanMethylation450 arrays on 354 anti-citrullinated protein antibodyassociated rheumatoid arthritis cases and 337 controls, we identified two clusters within the… Continue Reading