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Daily Archives: May 2, 2017

CRS – Advanced Gene Editing: CRISPR – Cas9

Advanced Gene Editing: CRISPR-Cas9, Congressional Research Service, April 28, 2017. [via FAS]

“Scientists have long sought the ability to control and modify DNA—the code of life. A new gene editing technology known as CRISPR-Cas9 offers the potential for substantial improvement over previous technologies in that it is simple to use and inexpensive and has a relatively high degree of precision and efficiency. These characteristics have led many in the scientific and business communities to assert that CRISPR-Cas9 will lead to groundbreaking advances in many fields, including agriculture, energy, ecosystem conservation, and the investigation, prevention, and treatment of diseases.Over the next 5 to 10 years, the National Academy of Sciences projects a rapid increase in the scale, scope, complexity, and development rate of biotechnology products, many enabled by CRISPR-Cas9. Concomitant with the promise of potential benefits, such advances may pose new risks and raise ethical concerns. For example, recent experiments by Chinese scientists and others that modified human embryos using CRISPR-Cas9 gene editing have sparked ethical debates, raising such concerns as how the genetic change would affect not only the immediate patient, but also future generations who would inherit the change without choice. Additionally, CRISPR-related approaches (i.e., gene drives) are being considered to reduce or eliminate the mosquito that serves as the primary vector for the transmission of Zika or malaria, thereby improving public health. Some scientists have raised ethical questions and expressed concerns about the unintended ecological consequences of eliminating a species or introducing a genetically modified organism into an open environment. Some experts assert that the current system for regulating biotechnology products—the Coordinated Framework for the Regulation of Biotechnology—may be inadequate, with the potential to leave gaps in oversight. Regulatory gaps may lead to increased uncertainty that could affect the development of future biotechnology products or a loss of public confidence in the ability of regulators to ensure that such products are safe. In the 115thCongress, policymakers may want to examine the potential benefits and risks associated with the use of CRISPR-Cas9 gene editing, including the ethical, social, and legal implications of CRISPR-related biotechnology products. Congress also may have a role to play with respect to regulation, research and development, and economic competitiveness associated with CRISPR-Cas9gene editing and future biotechnology products.”

Massive UAlbany death penalty archive goes digital

Daily Gazette: “During his life, M. Watt Espy searched libraries and courthouses across the country gradually building what is widely considered the most comprehensive record of executions in the country. For decades the archive sat in stacks of boxes in his Alabama home. Next year the archive, which is now housed on the far shelves… Continue Reading

Data Management: New Tools, New Organization, and New Skills in a French Research Institute

Martin, C., Cadiou, C. & Jannès-Ober, E., (2017). Data Management: New Tools, New Organization, and New Skills in a French Research Institute. LIBER Quarterly. 27(1), pp.73–88. DOI: “In the context of E-science and open access, visibility and impact of scientific results and data have become important aspects for spreading information to users and to… Continue Reading

Report – Combating Fake News: An Agenda for Research and Action

Combating Fake News: An Agenda for Research and Action. David Lazer, Matthew Baum, Nir Grinberg, Lisa Friedland, Kenneth Joseph, Will Hobbs, and Carolina Mattsson. May 2, 2017. “Recent shifts in the media ecosystem raise new concerns about the vulnerability of democratic societies to fake news and the public’s limited ability to contain it. Fake news… Continue Reading

Animation Maps Two Centuries of US Immigration

“Metrocosm is [a]collection of maps and other data visualization projects — trying to make sense of the world through numbers created by Max Galka, a guy who is fascinated by data. [His] latest project Blueshift is a tool for designing dynamic maps, like some of the ones I post here. My other current project, FOIA Mapper, aims to… Continue Reading

CDC – African American Health: Creating Equal Opportunities for Health

Cunningham TJ, Croft JB, Liu Y, Lu H, Eke PI, Giles WH. Vital Signs: Racial Disparities in Age-Specific Mortality Among Blacks or African Americans — United States, 1999–2015. MMWR Morb Mortal Wkly Rep. ePub: 2 May 2017. DOI: “The death rate for African Americans dropped 25% from 1999-2015, but they are still more likely… Continue Reading

The State of Black America Report

“The State of Black America®, the National Urban League’s seminal annual publication, now in its 41st edition, has become one of the most highly-anticipated benchmarks and sources for thought leadership around racial equality in America across economics, employment, education, health, housing, criminal justice and civic participation. Each edition of the State of Black America® contains… Continue Reading